bs-42406P

DATASHEET

Entrez Gene: 3156

Swiss Prot: P04035

Source: Recombinant human HMGCR protein is expressed in E.coli with N-His. It contains the amino acid sequence of 432-888/888

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Sequence: 432-888/888

Size: 100µg, 500µg, 20µg

Applications: Others

Mol. Wt.: 51.5

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.