bs-42411P

DATASHEET

Entrez Gene: 9966

Swiss Prot: O95150

Source: Recombinant human TNFSF15 protein is expressed in E.coliwith N-His. It contains the amino acid sequence of 72-251/251

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea

Storage: The product should be stored at -70°C or -20°C.

Background:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Sequence: 72-251/251

Size: 100ug, 500ug

Applications: Others

Mol. Wt.: 22.9

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.