bs-42415P

DATASHEET

Entrez Gene: 1581

Swiss Prot: P22680

Source: Recombinant human CYP7A1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 155-504/504

Storage Buffer: 20mM Tris-Hcl (pH=9.0) with 8M Urea and 0.3M L-Arg

Storage: The product should be stored at -70°C or -20°C.

Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010].

Sequence: 155-504/504

Size: 100ug, 500ug

Applications: Others

Mol. Wt.: 42.5

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.