bs-42417P

DATASHEET

Entrez Gene: 8856

Swiss Prot: O75469

Source: Recombinant human PXR protein is expressed in E.coli with Sumo & His. It contains the amino acid sequence of 56-233/434

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine; transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues.

Size: 100ug,500ug,20ug

Applications: Others()

Mol. Wt.: 34.6

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.