bs-42424P

DATASHEET

Entrez Gene: 20481

Swiss Prot: Q60698

Source: Recombinant mouse SKI protein is expressed in E.coli with GST&His. It contains the amino acid sequence of 248-453/728

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea

Storage: The product should be stored at -70°C or -20°C.

Background:

SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.

Sequence: 248-453/728

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 51.8

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.