bs-42439P

DATASHEET

Entrez Gene: 5795

Swiss Prot: Q12913

Source: Recombinant human PTPRJ protein is expressed in E.coli with N-His. It contains the amino acid sequence of 997-1337/1337

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Sequence: 997-1337/1337

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 42

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.