bs-42465P

DATASHEET

Entrez Gene: 197259

Swiss Prot: Q8NB16

Source: Recombinant human MLKL protein in E.coli with GST & His. It contains the amino acid sequence ofGST & His

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].

Sequence: 1-263/263

Size: 100µg, 500µg, 20µg

Applications: Others

Mol. Wt.: 60

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.