bs-42469P

DATASHEET

Entrez Gene: 11096

Swiss Prot: Q9UNA0

Source: Recombinant human ADAMTS5 protei in E.coli with N-His. It contains the amino acid sequence of 485-624/930

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

Sequence: 485-624/930

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 19.3

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.