bs-42478P

DATASHEET

Entrez Gene: 11093

Swiss Prot: Q76LX8

Source: Recombinant human ADAMTS13 protein in E.coli with N-His. It contains the amino acid sequence of 75-441/1427

Storage Buffer: 20mM Tris-Hcl (pH=8.0) with 8M Urea.

Storage: The product should be stored at -70°C or -20°C.

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].

Sequence: 75-441/1427

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 43

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.