bs-42478P-APC

DATASHEET

Entrez Gene: 11093

Swiss Prot: Q76LX8

Source: Recombinant human ADAMTS13 protein in E.coli with N-His. It contains the amino acid sequence of 75-441/1427

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100ug,500ug

Applications: Others()

Mol. Wt.: 43

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.