bs-42484P

DATASHEET

Entrez Gene: 1536

Swiss Prot: P04839

Source: Recombinant human NOX2 protein in E.coli with N-His. It contains the amino acid sequence of 283-570/570

Storage Buffer: 20mM Tris-HCL (pH=9.0) with 8M Urea

Storage: The product should be stored at -70°C or -20°C.

Background:

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.

Sequence: 283-570/570

Size: 100µg, 500µg

Applications: Others

Mol. Wt.: 35.6

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.