bs-42484P-Biotin

DATASHEET

Entrez Gene: 1536

Swiss Prot: P04839

Source: Recombinant human NOX2 protein in E.coli with N-His. It contains the amino acid sequence of 283-570/570

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ug,500ug

Applications: Others()

Mol. Wt.: 35.6

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.