bs-42649P

DATASHEET

Entrez Gene: 15357

Swiss Prot: Q01237

Source: Recombinant mouse HMGCR protein is expressed in E.coli with N-His. It contains the amino acid sequence of 587-885/887

Storage Buffer: 0.01M TBS(pH7.4)

Storage: Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

Background:

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Size: 100ug, 500ug

Applications: Others(N/A)

Mol. Wt.: 34.3 kDa

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.