bs-43090P-APC

DATASHEET

Entrez Gene: 3572

Swiss Prot: P40189

Source: Recombinant human IL-6R-Beta protein is expressed in HEK293 cell with C-hFc-His. It contains the amino acid sequence of 23-618/618

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Sequence: 23-618/618

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100µg, 500µg, 20µg

Applications: Others

Predicted Molecular Weight: 95.2

Cross Reactive Species: Others

For research use only. Not intended for diagnostic or therapeutic use.