bs-43090P-Biotin
[Conjugated Protein]
Recombinant human IL-6R-Beta protein, C-hFc-His (HEK293), Biotin Conjugated
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Entrez Gene:
3572
Swiss Prot:
P40189
Source:
Recombinant human IL-6R-Beta protein is expressed in HEK293 cell with C-hFc-His. It contains the amino acid sequence of 23-618/618
Storage Buffer:
Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.
Storage:
The product should be stored at -70°C or -20°C.
Background:
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]