bs-43092P

DATASHEET

Entrez Gene: 7040

Swiss Prot: P01137

Source: Recombinant human TGF Beta 1 protein is expressed in HEK293 cell with N-His. It contains the amino acid sequence of 30-390/390

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

Sequence: 30-390/390

Size: 100µg, 500µg, 20µg

Applications: Others

Mol. Wt.: 43.3

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.