bs-43113P

DATASHEET

Entrez Gene: 16153

Swiss Prot: P18893

Source: Recombinant mouse IL-10 protein is expressed in HEK293 cell with N-His. It contains the amino acid sequence of 19-178/178

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

Size: 100ug,500ug,20ug

Applications: Others()

Mol. Wt.: 20.6

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.