bs-43149P-Biotin

DATASHEET

Entrez Gene: 4582

Swiss Prot: P15941

Source: Recombinant human Mucin-1 protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 24-300/1255

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ug,500ug,20ug

Applications: Others()

Mol. Wt.: 28.3

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.