DATASHEET
Entrez Gene:
43740568
Swiss Prot:
P0DTC2
Source:
Recombinant SARS-Cov-2 Spike RBD protein (BA.5/Omicron) is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 319-537/1273
Storage Buffer:
0.01M TBS(pH7.4)
Storage:
The product should be stored at -70°C or -20°C.
Background:
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein.
Sequence:
319-537/1273