bs-43160P

DATASHEET

Entrez Gene: 3106

Swiss Prot: P01889

Source: Recombinant human HLA-B & Beta-2-MG Heterodimer protein is expressed in HEK293 cell with His&Avi . It contains the amino acid sequence of 25-309/362

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

Sequence: 25-309/362

Size: 100µg, 500µg, 20µg

Applications: Others

Mol. Wt.: 35.8

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.