bs-43201P

DATASHEET

Entrez Gene: 2217

Swiss Prot: P55899

Source: Recombinant human FCGRT&B2M Heterodimer protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 24-297/365&21-119

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.

Size: 100ug,500ug,20ug

Applications: Others()

Mol. Wt.: 31.8/11.7

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.