bs-43206P-APC

DATASHEET

Entrez Gene: 2217

Swiss Prot: P55899

Source: Recombinant mouse FCGRT&B2M Heterodimer protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 22-297/365&21-119/119

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100ug,500ug,20ug

Applications: Others()

Mol. Wt.: 33

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.