bs-43588P-Biotin

DATASHEET

Entrez Gene: 2057

Swiss Prot: P19235

Source: Recombinant human EPOR protein is expressed in HEK293 cell with C-His. It contains the amino acid sequence of 25-250/508

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

Sequence: 25-250/508

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µg, 500µg, 20µg

Applications: Others

Predicted Molecular Weight: 25.9

Cross Reactive Species: Others

For research use only. Not intended for diagnostic or therapeutic use.