bs-43702P-Biotin

DATASHEET

Entrez Gene: 947

Swiss Prot: P28906

Source: Recombinant human CD34 protein in HEK293 with C-His. It contains the amino acid sequence of 32-290/385

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Sequence: 32-290/385

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µg, 500µg, 20µg

Applications: Others

Predicted Molecular Weight: 29.4

Cross Reactive Species: Others

For research use only. Not intended for diagnostic or therapeutic use.