Target Protein: Bcl-2
Immunogen Range: 169-211/239
Entrez Gene: 596
Swiss Prot: P10415
Source: KLH conjugated synthetic peptide derived from human Bcl-2
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition: Store at -20°C for 12 months.
Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.