bs-4587R [Primary Antibody]
IL-6 Polyclonal Antibody
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]

Host: Rabbit

Target Protein: IL-6

Immunogen Range: 51-150/212

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3569

Swiss Prot: P05231

Source: KLH conjugated synthetic peptide derived from human IL-6

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.


Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 23

Cross Reactive Species: Human

Predicted Cross Reactive Species: Cow

For research use only. Not intended for diagnostic or therapeutic use.

  • Chen, Xiangzheng, et al. "Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling." Journal of Molecular Medicine 90.11 (2012): 1311-1319.Read more>>
  • Shuangjiao Deng et al. Uncovering the Anticancer Mechanism of Compound Sophorae Decoction against Ulcerative Colitis-Related Colorectal Cancer in Mice. Evidence-Based Complementary and Alternative Medicine, 2019, 1–16. Read more>>
  • Wang Y et al. H2S mediates apoptosis in response to inflammation through PI3K/Akt/NFκB signaling pathway. Biotechnol Lett. 2019 Dec 23. Read more>>
  • Yang W et al. The Effect of Low and High Dose Deoxynivalenol on Intestinal Morphology, Distribution, and Expression of Inflammatory Cytokines of Weaning Rabbits. Toxins (Basel). 2019 Aug 13;11(8). pii: E473.Read more>>
  • Xiaoli Gao. et al. Epigenetic upregulation of ssc-miR-124a following treatment with Clostridium perfringens beta2-toxin attenuates both apoptosis and inflammation in intestinal porcine epithelial cells. Arch Biochem Biophys. 2021 Apr;701:108806Read more>>
  • Franziska Widmayer. et al. Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures. INT J MOL SCI. 2023 Jan;24(7):6143Read more>>
  • Li Li. et al. Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway. BIOTECHNOL GENET ENG. 2023 Apr 26Read more>>
  • Kaijun Li. et al. Smart Lubricant Coating with Urease-Responsive Antibacterial Functions for Ureteral Stents to Inhibit Infectious Encrustation. ADV FUNCT MATER. 2023 Sep;:230776Read more>>

Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-IL-6 Polyclonal Antibody, Unconjugated (bs-4587R) at 1:200 followed by conjugation to the secondary antibody and DAB staining