bs-46110P-Cy5

DATASHEET

Swiss Prot: Q9BYF1

Source: Recombinant Human ACE2 is produced by Mammalian cells expression system and the target gene encoding Met1-Ser740 is expressed with C-His Tag

Storage Buffer: Lyophilized from 0.22um filtered solution in 20mM PB (pH 7.4). 5% trehalose is added as a protectant before lyophilization.

Storage: The product should be stored at -70°C or -20°C.

Background:

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, and heart, in the colon, small intestine, and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor, don‚Äôt inhibit ACE-2 activity. ACE-2 may play an essential role in regulating heart function.

Endotoxin: Not Tested

Purity: >95% as determined by SDS-PAGE

Sequence: Met1-Ser740

Expression: Mammalian cells

Tag: C-His

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ug

Mol. Wt.: 86.28kDa

Species: Human

For research use only. Not intended for diagnostic or therapeutic use.