bs-46210P

DATASHEET

Entrez Gene: 916

Swiss Prot: P07766

Source: Recombinant human CD3E protein, C-His (HEK293) protein is expressed in HEK293 with C-His. It contains the amino acid sequence of 1-126/207.

Storage Buffer: 0.01M TBS(pH7.4)

Storage: The product should be stored at -70°C or -20°C.

Background:

CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Sequence: 1-126/207

Size: 100µg, 500µg, 20µg

Applications: ELISA

Mol. Wt.: 12.69

Species: Others

For research use only. Not intended for diagnostic or therapeutic use.