bs-4886R [Primary Antibody]
TREM1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: TREM1

Specificity: Antibody's immunogen sequence has 69% homology to the Human TREM1 protein

Immunogen Range: 65-150/230


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 58217

Swiss Prot: Q9JKE2

Source: KLH conjugated synthetic peptide derived from mouse TREM1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 23


Cross Reactive Species: Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Zhao,et al.Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats.(2018) Molecular and Cellular Endocrinology. :.Read more>>
  • Teng,et al.Anti-inflammatory effect of tranexamic acid against trauma-hemorrhagic shock-induced acute lung injury in rats.(2018) Experimental Animals. :.Read more>>
  • Nurettin Aydoğdu et al. The Effects of Irisin on Nω-Nitro-L-arginine Methyl Ester Hydrochloride-Induced Hypertension in Rats. Balkan Med J 2019;36:337-46.Read more>>
  • Amir Boufenzer. et al. Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis. Cell Mol Immunol. 2021 Jan;18(2):452-46Read more>>
  • Zhi Chen. et al. Klotho deficiency aggravates diabetes-induced podocyte injury due to DNA damage caused by mitochondrial dysfunction. Int J Med Sci. 2020; 17(17): 2763C2772Read more>>
  • Liu, Xuanyu. et al. Single-cell RNA sequencing identifies an Il1rn+/Trem1+ macrophage subpopulation as a cellular target for mitigating the progression of thoracic aortic aneurysm and dissection. Cell Discov. 2022 Feb;8(1):1-21Read more>>
  • Liu, Xuanyu. et al. Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema. CELL DISCOV. 2022 Jun;8(1):1-2Read more>>
  • Chunchun Tang. et al. The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders. J NEUROIMMUNOL. 2023 Mar;:57807Read more>>
VALIDATION IMAGES

Rat Liver lysates probed with TREM1 Polyclonal Antibody, Unconjugated (bs-4886R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.