bs-4904R

DATASHEET

Host: Rabbit

Target Protein: SGK1

Clonality: Polyclonal

Isotype: IgG

Source: KLH conjugated synthetic peptide derived from human SGK1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation.

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:400-800)
IHC-F(1:400-800)
IF(1:100-500)

Cross Reactive Species: Human
Mouse
Rat
Bovine
Dog

For research use only. Not intended for diagnostic or therapeutic use.