bs-4905R-Cy5 [Conjugated Primary Antibody]
SORBS2 Polyclonal Antibody, Cy5 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: SORBS2

Immunogen Range: 401-500/664


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8470

Swiss Prot: O94875

Source: KLH conjugated synthetic peptide derived from human SORBS2/ArgBP2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.

Conjugation: Cy5

Excitation/ Emission: 625,650nm/670nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 124


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Pig
Horse
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tong,et al.HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells.(2018) Biochimica Et Biophysica Acta. 1864:1104-1114.Read more>>
  • Han L et al. The RNA‐binding protein SORBS2 suppresses hepatocellular carcinoma tumorigenesis and metastasis by stabilizing RORA mRNA. Liver Int. 2019 Jul 31. Read more>>
  • Yue Deng. et al. ARID5B promoted the histone demethylation of SORBS2 and hampered the metastasis of ovarian cancer. PATHOL RES PRACT. 2023 Dec;252:154911Read more>>
  • eibei Wang. et al. The RNA-binding protein sorbin and SH3 domain-containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor. MOL CARCINOGEN. 2024 MaRead more>>