bs-4963R [Primary Antibody]
C-Myc tag Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: C-Myc

Immunogen Range: 101-200/439


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4609

Swiss Prot: P01106

Source: KLH conjugated synthetic peptide derived from human C-Myc

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
ICC(1:100-500)

Predicted Molecular Weight: 49


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Sheep
Pig
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Jiang, Xiao-Hua, et al. "Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway." BMC microbiology 17.1 (2017): 124.Read more>>
  • Shi et al. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. (2015) Stem.Cell.Res.Ther. 6:120Read more>>
  • Ma W et al. A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway. Eur J Pharmacol. 2019 Apr 15;849:43-49. Read more>>
  • Wang J et al. Influence of calcium supplementation against fluoride-mediated osteoblasts impairment in vitro: Involvement of canonical Wnt/β-catenin signaling pathway. J Agric Food Chem. 2019 Sep 4. Read more>>
  • Li B et al. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. 2019 Nov 3;429:152312.Read more>>
  • Li YH et al. Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis. Carbohydrate Polymers 230 (2020) 1157.Read more>>
  • Niu K et al. Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation. PLoS One. 2020 Jan 15;15(1):e0227408.Read more>>
  • Zhao B et al. Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit. Genome. 2020 Jan 9:1-9. Read more>>
  • Niu K et al. Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation. PLoS One. 2020 Jan 15;15(1):e0227408.Read more>>
  • Chen Y et al. PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/\catenin signalling pathway. J Cell Mol Med. 2020 Jul;24(13):7405-7416.Read more>>
  • Yang Lv. et al. TGF-1 enhanced myocardial differentiation through inhibition of the Wnt/-catenin pathway with rat BMSCs. Iran J Basic Med Sci. 2020 Aug; 23(8): 1012C1019Read more>>
  • Mahmoud Labibet al. Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting. Nat Biomed Eng. 2020 Jul 27.Read more>>
  • Gong Y et al. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesisFood Chem Toxicol.2021 Jan;147:111912.Read more>>
  • Min Pengxiang. et al. MICAL-L2 Is Essential for c-Myc Deubiquitination and Stability in Non-small Cell Lung Cancer Cells. Front Cell Dev Biol. 2021 Jan;8:1798Read more>>
  • Shi, Ningning. et al. Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids. Nat Biomed Eng. 2021 Aug;:1-12Read more>>
  • Emeric Limagne. et al. MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells. Cancer Cell. 2022 JaRead more>>
  • Meiju Zhang. et al. The role of E2A in ATPR-induced cell differentiation and cycle arrest in acute myeloid leukaemia cells. J Cell Mol Med. 2022 Feb;26(4):1128-1143Read more>>
  • Xiaowei Qin. et al. Neddylation inactivation affects cell cycle and apoptosis in sheep follicular granulosa cells. J CELL PHYSIOL. 2022 May 16Read more>>
  • Feng Ziqiang. et al. In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides). FRONT PHYSIOL. 2022 May;0:811Read more>>
  • Ziqiang Feng. et al. Breed-specific expression mode of the Wnt signalling pathway is involved in feather follicle morphogenesis between Anser cygnoide and Anser anser. J APPL ANIM RES. 2022;50(1):299-306Read more>>
  • Yayun Xu. et al. Acid sensor ASIC1a induces synovial fibroblast proliferation via Wnt/-catenin/c-Myc pathway in rheumatoid arthritis. INT IMMUNOPHARMACOL. 2022 Dec;113:109328Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded human gastric cancer labeled with Anti-C-Myc Polyclonal Antibody, Unconjugated (bs-4963R) at 1:200 followed by conjugation to the secondary antibody and DAB staining\n