bs-5068R-APC [Conjugated Primary Antibody]
HMGCR Polyclonal Antibody, APC Conjugated
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Host: Rabbit

Target Protein: HMGCR

Immunogen Range: 251-350/888


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3156

Swiss Prot: P04035

Source: KLH conjugated synthetic peptide derived from human HMGCR

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Conjugation: APC

Excitation/ Emission: 650nm/660nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:1000-5000)

Predicted Molecular Weight: 97


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Lee, Myoung-Sun, et al. "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)."BMC Complementary and Alternative Medicine 16.1 (2016): 1.Read more>>
  • Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016).Read more>>
  • Yu, Fei, et al. "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." Journal of Huazhong University of Science and Technology [Medical Sciences] 36.5 (2016): 683-690.Read more>>
  • Ma et al. Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. (2017) Sci.Rep. 7:44819Read more>>
  • Fu et al. Lack of ClC-2 Alleviates High Fat Diet-Induced Insulin Resistance and Non-Alcoholic Fatty Liver Disease. (2018) Cell.Physiol.Biochem. 45:2187-2200Read more>>
  • Hu ZB et al. Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis. Theranostics. 2020 Feb 3;10(6):2803-2816.Read more>>
  • Hu ZB et al. Dysbiosis of intestinal microbiota mediates tubulointerstitial injury in diabetic nephropathy via the disruption of cholesterol homeostasis. Theranostics. 2020 Feb 3;10(6):2803-2816.Read more>>
  • Tan W et al. Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7-hydroxylase and lipoprotein lipase. Eur J Pharm Sci. 2020 Aug 1;151:105402.Read more>>
  • Wen-Long Sun. et al. Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota. Cell Rep. 2021 Aug;36:109641Read more>>
  • Gang Luo. et al. Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice. MOLECULES. 2022 Jan;27(15):4966Read more>>
  • Shuzhou Wang. et al. Effects of NAC assisted insulin on cholesterol metabolism disorders in canine type 1 diabetes mellitus. LIFE SCI. 2022 Dec;:121193Read more>>