bs-5081R-A750

DATASHEET

Host: Rabbit

Target Protein: Lamin B Receptor

Specificity: The immunogen for this product has partial sequence similarity to SEPT8 and SEPT2

Immunogen Range: 1-100/615

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3930

Swiss Prot: Q14739

Source: KLH conjugated synthetic peptide derived from human Lamin B Receptor

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization. Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. The cleavage of lamins results in nuclear disregulation and cell death.

Conjugation: ALEXA FLUOR® 750

Excitation/ Emission: 749nm/775nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 68

Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Cow
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.