bs-51025R

DATASHEET

Host: Mouse

Target Protein: ORC2

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 4999

Swiss Prot: Q13416

Source: Monoclonal antibody raised in mouse against human ORC2, using two recombinant proteins containing the N-terminal and C-terminal part of the protein, respectively

Purification: Protein G purified monoclonal antibody in PBS containing 0.05% azide.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.

Size: 50ug

Concentration: 0.6ug/ul

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.