bs-51058R

DATASHEET

Host: Rabbit

Target Protein: MBD2

Clonality: Polyclonal

Isotype: Not determined

Entrez Gene: 8932

Swiss Prot: Q9UBB5

Source: Polyclonal antibody raised in rabbit against mouse MBD2, using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein

Purification: Whole antiserum from rabbit containing 0.05% azide

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Size: 100µL

Concentration: Not Determined

Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.