bs-5137R [Primary Antibody]
TFEB Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: TFEB

Immunogen Range: 201-300/476


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7942

Source: KLH conjugated synthetic peptide derived from human TFEB

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
FCM(1:20-100)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 52


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Pig
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Kawano, Haruna, et al. "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." Oncology Reports 34.5 (2015): 2251-2258.Read more>>
  • Yujia Zhou. et al. Lysosome-mediated mitochondrial apoptosis induced by Tea polysaccharide promotes colon cancer cell death. Food Funct. 2021 SepRead more>>
  • Ke Zhang. et al. Aloe gel glucomannan induced colon cancer cell death via mitochondrial damage-driven PINK1/Parkin mitophagy pathway. CARBOHYD POLYM. 2022 Nov;295:119841Read more>>
  • Liu Haoge. et al. Number 2 Feibi Recipe Ameliorates Pulmonary Fibrosis by Inducing Autophagy Through the GSK-3_/mTOR Pathway. FRONT PHARMACOL. 2022 Jul;0:2714Read more>>
  • Juan Cen. et al. A Water-Soluble Quercetin Conjugate with Triple Targeting Exerts Neuron-Protective Effect on Cerebral Ischemia by Mitophagy Activation. ADV HEALTHC MATER. 2022 Sep;:2200817Read more>>
  • Shu-wen Xu. et al. Cigarette smoke extract-induced inflammatory response via inhibition of the TFEB-mediated autophagy in NR8383 cells. EXP LUNG RES. 2023 Jan 13Read more>>
  • Tingkui Zhao. et al. A Triple-Targeted Rutin-Based Self-Assembled Delivery Vector for Treating Ischemic Stroke by Vascular Normalization and Anti-Inflammation via ACE2/Ang1-7 Signaling. ACS CENTRAL SCI. 2023;XXXX(XXX):XXX-XXXRead more>>
  • Qu Yi. et al. Targeted Down-Regulation of SRSF1 Exerts Anti-Cancer Activity in OSCC Through Impairing Lysosomal Function and Inducing Autophagy. ISCIENCE. 2023 Jun 15Read more>>
  • Ziwei Wang. et al. Agrocybe cylindracea fucoglucogalactan induced lysosome-mediated apoptosis of colorectal cancer cell through H3K27ac-regulated cathepsin D. CARBOHYD POLYM. 2023 Jul;:121208Read more>>