Target Protein: NMDAR2B Tyr1252
Specificity: This antibody may cross react with NMDAR2A (Tyr 1246) due to 75% sequence similarity.
Modification Site: Tyr1252
Entrez Gene: 2904
Swiss Prot: Q13224
Source: KLH conjugated synthetic phosphopeptide derived from human NMDAR2B around the phosphorylation site of Tyr1252
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage: Store at -20°C for 12 months..
Background: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
Predicted Molecular Weight: 164
Cross Reactive Species: Rat
Predicted Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.