bs-5447R [Primary Antibody]
IGF1R (Tyr980) Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: IGF1R Tyr980

Immunogen Range: 960-1000/1367

Modification Site: Tyr980

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3480

Swiss Prot: P08069

Source: KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr980

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.

Storage Condition: Store at -20°C for 12 months.

Background: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-1000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Tang, Hexiao, et al. "Estrogen and insulin?\like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice."International Journal of Cancer (2013)..Read more>>
  • Lee, Yongik, et al. "Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells." Molecular Carcinogenesis (2015).Read more>>
  • Tang et al. Estrogen and insulin-like growth factor 1 synergistically promote the development of lung adenocarcinoma in mice. (2013) Int.J.Cancer. 133:2473-82Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded human kidney carcinoma labeled with Anti phospho-IGF1R(Tyr980) Polyclonal Antibody,Unconjugated (bs-5447R) at 1:200 followed by conjugation to the secondary antibody and DAB staining