Target Protein: IGF1R Tyr980
Immunogen Range: 960-1000/1367
Modification Site: Tyr980
Entrez Gene: 3480
Swiss Prot: P08069
Source: KLH conjugated synthetic phosphopeptide derived from human IGF1R around the phosphorylation site of Tyr980
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition: Store at -20°C for 12 months.
Background: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.