bs-55012R

DATASHEET

Host: Rabbit

Target Protein: APEX1

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 328

Swiss Prot: P27695

Source: Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1 (NP_542380.1).

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Size: 100uL

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IP(1-2ug)
IF(1:50-200)

Predicted Molecular Weight: 35kDa

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.