bs-55038R

DATASHEET

Host: Rabbit

Target Protein: CCND3

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 896

Swiss Prot: P30281

Source: Recombinant fusion protein containing a sequence corresponding to amino acids 201-292 of human CCND3 (NP_001751.1).

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.

Size: 100uL

Concentration: 1ug/ul

Applications: WB(1:300-5000)

Predicted Molecular Weight: 9kDa/22kDa/24kDa/32kDa

Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.