DATASHEET
Host:
Rabbit
Target Protein:
DPYSL2
Clonality:
Polyclonal
Isotype:
IgG
Entrez Gene:
1808
Swiss Prot:
Q16555
Source:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human DPYSL2 (NP_001377.1).
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
VALIDATION IMAGES
Lane 1: Hela cell lysates; Lane 2: DPYSL2 knockout (KO) HeLa cell lysates probed with DPYSL2 Polyclonal Antibody, Unconjugated (bs-55057R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.
Lane 1: HepG2 cell lysates; Lane 2: U-251MG cell lysates; Lane 3: 293T cell lysates probed with DPYSL2 Polyclonal Antibody, Unconjugated (bs-55057R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.