bs-55069R

DATASHEET

Host: Rabbit

Target Protein: ERK2

Specificity: KO-Validated

Immunogen Range: 200-300/360

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5594

Swiss Prot: P28482

Source: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2 (NP_620407.1).

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Size: 100ul, 20uL

Concentration: Lot Dependent

Applications: WB(1:300-5000)
ELISA(1:500-1000)

Predicted Molecular Weight: 41

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.