bs-55107R

DATASHEET

Host: Rabbit

Target Protein: IDE

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3416

Swiss Prot: P14735

Source: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IDE (NP_004960.2).

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IF(1:50-200)
IHC-P(1:200-400)

Predicted Molecular Weight: 54kDa/117kDa

Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.