bs-5512R-PE [Conjugated Primary Antibody]
NFKB1 (Ser337) Polyclonal Antibody, PE Conjugated
www.biossusa.com
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DATASHEET

Host: Rabbit

Target Protein: NFKB1 Ser337

Modification Site: Ser337

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 4790

Source: KLH conjugated synthetic phosphopeptide derived from human NF KappaB p105 around the phosphorylation site of Ser337

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
FCM(1:20-100)

Predicted Molecular Weight: 48/105


Cross Reactive Species: Human
Mouse
Others

Predicted Cross Reactive Species: Cow
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Lei Zhao. et al. Proteomic analysis reveals the molecular mechanism of Hippophae rhamnoides polysaccharide intervention in LPS-induced inflammation of IPEC-J2 cells in piglets. Int J Biol Macromol. 2020 Dec;164:3294Read more>>
  • Chen Bai. et al. Ac2?26 alleviates hepatic ischemia?reperfusion injury based on inhibiting the positive feedback loop of HMGB1/TLR4/NF?B/neutrophils. EXP THER MED. 2022 Nov;24(5):1-1Read more>>
  • Houpan Song. et al. Traditional Chinese Medicine prescription Huang-Qi-Jian-Zhong-Tang ameliorates indomethacin-induced duodenal ulcers in rats by affecting NF-B and STAT signaling pathways. BIOMED PHARMACOTHER. 2022 Dec;156:113866Read more>>
  • Lisha Peng. et al. miR-128-3p increases the radiosensitivity in nasopharyngeal carcinoma via regulating vascular endothelial growth factor C. PATHOL RES PRACT. 2023 Aug;:154768Read more>>
VALIDATION IMAGES