bs-55131R-PerCP-Cy5.5

DATASHEET

Host: Rabbit

Target Protein: MLKL

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 74568

Swiss Prot: Q9D2Y4

Source: Recombinant protein of mouse MLKL

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Conjugation: PerCP-Cy5.5

Excitation/ Emission: 482nm/694nm

Size: 100ul

Concentration: 1mg/ml

Applications: WB(1:500-2000)

Predicted Molecular Weight: 54 kDa

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.