bs-55165R [Primary Antibody]
PDCD10 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: PDCD10

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 11235

Swiss Prot: Q9BUL8

Source: Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_009148.2).

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 24kDa


Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Lane 1: Hela cell lysates; Lane 2: PDCD10 knockout (KO) HeLa cell lysates probed with PDCD10 Polyclonal Antibody, Unconjugated (bs-55165R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.


Lane 1: A431 cell lysates; Lane 2: HepG2 cell lysates; Lane 3: Jurkat cell lysates; Lane 4: MCF-7 cell lysates; Lane 5: Mouse Thymus lysates; Lane 6: Mouse Brain lysates probed with PDCD10 Polyclonal Antibody, Unconjugated (bs-55165R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.