bs-55182R-PerCP

DATASHEET

Host: Rabbit

Target Protein: PTPN1

Specificity: KO-Validated

Immunogen Range: 281-435/435

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5770

Swiss Prot: P18031

Source: Recombinant fusion protein containing a sequence corresponding to amino acids 281-435 of human PTPN1 (NP_002818.1).

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.

Conjugation: PerCP

Excitation/ Emission: 482nm/677nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(1:500-2000)
IF(1:100-500)
Flow-Cyt(1ug/Test)

Predicted Molecular Weight: 48

Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Cow
Pig
Horse
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.