bs-5768R [Primary Antibody]
FGF23 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: FGF23

Immunogen Range: 21-120/251


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 8074

Swiss Prot: Q9GZV9

Source: KLH conjugated synthetic peptide derived from human FGF23

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 27


Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human
Mouse
Dog
Cow
Sheep
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Andersen, Ingrid A., et al. "Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure." Nephrology Dialysis Transplantation (2015): gfv398.Read more>>
  • Stenhouse Claire. et al. Novel Mineral Regulatory Pathways in Ovine Pregnancy: I. Phosphate, Klotho Signaling, and Sodium Dependent Phosphate Transporters. Biol Reprod. 2021 FebRead more>>
  • Ping Wang. et al. Iron Sucrose: A Double-Edged Sword in High Phosphate Media-Induced Vascular Calcification. 2021 Jan 13Read more>>
  • Koichiro Kajiwara. et al. Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy. Bmc Nephrol. 2021 Dec;22(1):1-12Read more>>
  • Stenhouse Claire. et al. Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling. Biol Reprod. 2022 FebRead more>>
  • Cheng-Ken Tsai. et al. Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats. TOXICS. 2022 May;10(5):238Read more>>
  • Zhang Hongqi. et al. Promotion effect of FGF23 on osteopenia in congenital scoliosis through FGFr3/TNAP/OPN pathway. CHINESE MED J-PEKING. 2023 May;:10.1097/CM9.000000000000269Read more>>
  • Li Lei. et al. LncRNA 152 attenuates lipopolysaccharide-induced acute kidney injury in rats by regulating the FGF23/Klotho/MAPK axis. NEPHROLOGY. 2023 SepRead more>>
VALIDATION IMAGES

Lane 1: Rat Bone lysates; Lane 2: Rat Cerebrum lysates probed with FGF23 Polyclonal Antibody, Unconjugated (bs-5768R) at 1:1000 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.