bs-5913R-A647
[Conjugated Primary Antibody]
Calreticulin Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
DATASHEET
Host: Rabbit
Target Protein: Calreticulin
Immunogen Range: 101-200/417
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 811
Swiss Prot: P27797
Source: KLH conjugated synthetic peptide derived from human Calreticulin
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Conjugation: ALEXA FLUOR® 647
Excitation/ Emission: 650nm/665nm
Size: 100ul
Concentration: 1ug/ul
Applications:
WB(1:300-5000)
FCM(1:20-100)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)
Predicted Molecular Weight: 44
Cross Reactive Species:
Human
Mouse
Rat
Predicted Cross Reactive Species:
Dog
Cow
Pig
Horse
Chicken
Rabbit
Guinea Pig
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
- Angelova, Assia L., et al. "Complementary induction of immunogenic cell death by oncolytic parvovirus H-1PV and gemcitabine in pancreatic cancer." Journal of Virology (2014): JVI-03688.Read more>>
- Chen, Beilei, et al. "Calreticulin Binds to Fas Ligand and Inhibits Neuronal Cell Apoptosis Induced by Ischemia-reperfusion Injury." BioMed Research International.Read more>>
- Tanaka, Mamoru, et al. "Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin)." Oncotarget (2016).Read more>>
- Erbas et al. Oxytocin alleviates cisplatin-induced renal damage in rats. (2014) Iran.J.Basic.Med.Sci. 17:747-52Read more>>
- An J et al. Nanoenabled Disruption of Multiple Barriers in Antigen Cross-Presentation of Dendritic Cells via Calcium Interference for Enhanced Chemo-Immunotherapy. ACS Nano 2020 06 23;146(6)Read more>>
- Rui X et al. Imperative and effective reversion of synovial hyperplasia and cartilage destruction in rheumatoid arthritis through multiple synergistic effects of O2 and Ca2+. Mater Sci Eng C Mater Biol Appl.2020 Sep;114:111058.Read more>>
- Hiroshi Fukushima. et al. Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation AntiCPD-1 Treatment Efficacy in Urothelial Carcinoma. Int J Mol Sci. 2021 Jan;22(2):535Read more>>
- Hiroshi Fukushima. et al. Combination of Cisplatin and Irradiation Induces Immunogenic Cell Death and Potentiates Postirradiation AntiCPD-1 Treatment Efficacy in Urothelial Carcinoma. Int J Mol Sci. 2021 Jan;22(2):535Read more>>
- Qilin Li. et al. IDO-inhibitor potentiated immunogenic chemotherapy abolishes primary tumor growth and eradicates metastatic lesions by targeting distinct compartments within tumor microenvironment. Biomaterials. 2021 Feb;269:120388Read more>>
- Kai Sun. et al. Reinforcing the Induction of Immunogenic Cell Death Via Artificial Engineered Cascade Bioreactor-Enhanced Chemo-Immunotherapy for Optimizing Cancer Immunotherapy. 2021 Aug 06Read more>>
- Chavez-Dominguez RL. et al. Role of HMGB1 in Cisplatin-Persistent Lung Adenocarcinoma Cell Lines.. Front Oncol. 2021 Dec;11:750677-750677Read more>>
- Yuting Shen. et al. Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation. Acs Nano. 2021;XXXX(XXX):XXX-XXXRead more>>
- Ruikun Wang. et al. CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model. J Immunother Cancer. 2022 Jan;10(1):e003809Read more>>
- owei Chen. et al. iRGD Tumor-Penetrating Peptide-Modified Nano-Delivery System Based on a Marine Sulfated Polysaccharide for Enhanced Anti-Tumor Efficiency Against Breast Cancer. Int J Nanomed. 2022 Feb;17:617-633Read more>>
- Zhenzhen Chen. et al. Photothermal MnO2 nanoparticles boost chemo-photothermal therapy-induced immunogenic cell death in tumor immunotherapy. Int J Pharmaceut. 2022 Apr;617:121578Read more>>
- Xiu Zhao. et al. Intracellular Self-Assembly Driven Nucleus-Targeted Photo-Immune Stimulator with Chromatin Decompaction Function for Robust Innate and Adaptive Antitumor Immunity. Adv Funct Mater. 2022 Apr;32(17):2108883Read more>>
- Wei Jiang. et al. Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy. Acs Nano. 2022;XXXX(XXX):XXX-XXXRead more>>
- Feng Liu. et al. LncRNA-targeting bio-scaffold mediates triple immune effects for postoperative colorectal cancer immunotherapy. Biomaterials. 2022 May;284:121485Read more>>
- Pan Zhang. et al. The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment. BIOMATERIALS. Biomaterials. 2022 Apr;:121518Read more>>
- Kai Sun. et al. Salicylic acid-based hypoxia-responsive chemodynamic nanomedicines boost antitumor immunotherapy by modulating immunosuppressive tumor microenvironment. ACTA BIOMATER. 2022 JuRead more>>
- Shohei Katsuki. et al. Radiation therapy enhances systemic antitumor efficacy in PD-L1 therapy regardless of sequence of radiation in murine osteosarcoma. PLOS ONE. 2022 Jul;17(7):e0271205Read more>>
- Nan Zhang. et al. Co-Delivery of Doxorubicin and Anti-PD-L1 Peptide in Lipid/PLGA Nanocomplexes for the Chemo-Immunotherapy of Cancer. MOL PHARMACEUT. 2022;19(9):34393449Read more>>
- Yanhua Zhai. et al. Self-activated arsenic manganite nanohybrids for visible and synergistic thermo/immuno-arsenotherapy. J CONTROL RELEASE. 2022 Oct;350:761Read more>>
- Axel Berg-Larsen. et al. Tumor growth inhibition and immune system activation following treatment with thorium-227 conjugates and PD-1 check-point inhibition in the MC-38 murine model.. FRONT MED-LAUSANNE. 2022 Nov;9:1033303-1033303Read more>>
- Nguyen Thi Nguyen. et al. Amplified Fenton-Based Oxidative Stress Utilizing Ultraviolet Upconversion Luminescence-Fueled Nanoreactors for Apoptosis-Strengthened Ferroptosis Anticancer Therapy. ACS NANO. 2022;XXXX(XXX):XXX-XXXRead more>>
- Qilin Li. et al. NIR-responsive hollow germanium nanospheres mediate photothermal/photodynamic therapy and restrain immunosuppression to cooperatively eradicate primary and metastatic tumors. CHEM ENG J. 2023 Jan;:141314Read more>>
- Ning Han. et al. Dihydroartemisinin elicits immunogenic death through ferroptosis-triggered ER stress and DNA damage for lung cancer immunotherapy. PHYTOMEDICINE. 2023 Jan;:154682Read more>>
- Ting-Ting Yu. et al. Chlorin e6-induced photodynamic effect facilitates immunogenic cell death of lung cancer as a result of oxidative endoplasmic reticulum stress and DNA damage. INT IMMUNOPHARMACOL. 2023 Feb;115:109661Read more>>
- Xiao Wu. et al. Nanodrug constructed using dietary antioxidants for immunotherapy of metastatic tumors. J MATER CHEM B. 2023 FebRead more>>
- Xianquan Feng. et al. Drug Self-Delivery Nanocubes Enhance O2-Economized Photodynamic-Immunotherapy of Triple-Negative Breast Cancer by Downregulating Wnt/-catenin Signaling. ADV HEALTHC MATER. 2023 Apr;:2203019Read more>>
- Kai Sun. et al. Photothermal enhanced polyphenol-based nanofibers ameliorate catalytic efficiency of ferroptosis for synergistic tumor therapy. CHEM ENG J. 2023 Aug;470:14436Read more>>
- Shengchang Tao. et al. Dendrobium officinale polysaccharide-based carrier to enhance photodynamic immunotherapy. CARBOHYD POLYM. 2023 Oct;317:121089Read more>>
- Ziyang Zhu. et al. Aggregation-Induced Emission Photosensitizer/Bacteria Biohybrids Enhance Cerenkov Radiation-Induced Photodynamic Therapy by Activating Anti-Tumor Immunity for Synergistic Tumor Treatment. ACTA BIOMATER. 2023 JuRead more>>
- Shiyu Liu. et al. OX40L-Armed Oncolytic Virus Boosts T-cell Response and Remodels Tumor Microenvironment for Pancreatic Cancer Treatment. THERANOSTICS. 2023; 13(12): 4016C4029Read more>>
- Fukushima Hiroshi. et al. Intratumoral interleukin-15 improves efficacy of near-infrared photoimmunotherapy. MOL CANCER THER. 2023 JulRead more>>
- Liu-Gen Li. et al. A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage. ADV HEALTHC MATER. 2023 Aug;:2301561Read more>>
- Ziwen Qiu. et al. Self-reinforced photodynamic immunostimulator to downregulate and block PD-L1 for metastatic breast cancer treatment. BIOMATERIALS. 2023 Dec;303:122392Read more>>
- Peng Xue. et al. Fe3+ mediated shikonin and PPA coloaded liposomes induce robust immunogenic cell death by integrating ROS enhancement and GSH depletion. INT J PHARMACEUT. 2024 Jan;649:123657Read more>>
- Yaoqi Li. et al. Long-Acting Nanohybrid Hydrogel Induces Persistent Immunogenic Chemotherapy for Suppressing Postoperative Tumor Recurrence and Metastasis. MOL PHARMACEUT. 2023;XXXX(XXX):XXX-XXXRead more>>
- Wangxian Fu. et al. A programmable releasing versatile hydrogel platform boosts systemic immune responses via sculpting tumor immunogenicity and reversing tolerogenic dendritic cells. BIOMATERIALS. 2024 Mar;305:122444Read more>>
- Ren-Jiang Kong. et al. Self-Delivery Photodynamic Re-educator Enhanced Tumor Treatment by Inducing Immunogenic Cell Death and Improving Immunosuppressive Microenvironments. ACS APPL MATER INTER. 2023;15(51):59165C59174Read more>>
VALIDATION IMAGES